m-Tolylacetic acid → N-[(3-methylphenyl)acetyl]alanine Iso-butyl Ester

HRID 428105Notes

Reaction equation

HRID 428105 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH2:19])[CH:13]([CH3:15])[CH3:14]>>[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH:19][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=1)[CH:13]([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 12121m-Tolylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 53803690N-[(3-methylphenyl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure I above, and using 3-methylphenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purificatioin was by filtration as described in the general procedure.

Workup

  1. filtrationwas by filtration

Sources & evidence

ORD record
ord-a797a8ee2de043d38320663c68619536
Source dataset
uspto-grants-2001_11
Patent number
US06313152B1

Reaction notes

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