3-Thiophenacetic acid → N-[(3thienyl)acetyl]alanine Iso-butyl Ester

HRID 428108Notes

Reaction equation

HRID 428108 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([OH:9])=O)=[CH:2]1.[CH2:10]([O:14][C:15](=[O:26])[C@H:16]([CH3:25])[NH:17]C(=O)CC(C)CC)[CH:11]([CH3:13])[CH3:12]>>[CH2:10]([O:14][C:15](=[O:26])[C@H:16]([CH3:25])[NH:17][C:7](=[O:9])[CH2:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)[CH:11]([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 234043-Thiophenacetic acidHCID 15481764N-(3-methylpentanoyl)-L-alanine Isobutyl Ester

Product 1

HCID 53969374N-[(3thienyl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure I above, and using 3-thiopheneacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure 3 above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-0f47dbed14924cc285fb78d2c3a72cc8
Source dataset
uspto-grants-2001_11
Patent number
US06313152B1

Reaction notes

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