Piperidine → HCID 12051145, compound

Participants

Reaction Steps

Then, ethanol (10 ml), 3-pyridinecarbaldehyde (0.62 g, 5.8 mmol) and a drop of piperidine were added to the resulting 2-cyano-N-(4-methoxymethoxyphenethyl)acetamide (0.96 g, 3,87 mmol) and refluxed under heating for 19 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (chloroform:methanol=19:1) and recrystallized to yield the titled compound (0.83 g, 64%). Properties: mp 105-106° C. (ethyl acetate-hexane)

Provenance & Evidence