2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 23067304, compound

Participants

Reaction Steps

To a solution of (E)-N-[2-hydroxy-2-(3-methoxy-4-hydroxyphenyl)ethyl]-N-methyl-3-(3-pyridyl)-2-propenoic acid amide (656 mg, 2 mmol) in dioxane (12 ml), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (468 mg, 2 mmol) was added under argon and stirred at room temperature for 2 hours. After the precipitated crystal was filtered out, the solvent was distilled out under reduced pressure and the residue was purified by column chromatography (chloroform:methanol=50:1) and dried under reduced pressure to yield the titled compound (362 mg, 56%).

Provenance & Evidence