Aluminum(III) Chloride → 1,4-Benzodioxin-6-carboxaldehyde, 2,3-dihydro-7-hydroxy-

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Reaction Steps

4 eq. of AlCl3 are suspended in 10 ml of anhydrous CH2Cl2. Under an inert atmosphere, 100 mg (5.55 mmol) of the compound obtained in Step C, dissolved in 10 ml of anhydrous CH2Cl2, are added to that mixture and allowed to act for 2 hours at ambient temperature. The mixture is hydrolysed with an ice-cold 2N HCl solution; the solution is then extracted with CH2Cl2 and dried over MgSO4. After evaporation of the solvent, purification on a silica column (eluant:PE/AcOEt 7/3) is carried out and the pure product is isolated.

Provenance & Evidence