反应详情

A mixture of 4-methoxyphenol (10 g:80.5 mmol) and Triton B (2.29 ml:14.5 mmol 0. 18 eq.) in acrylonitrile (50 ml) is heated at reflux for 48 hours. After the solvent has been partially removed, the products are extracted with ethyl acetate and washed with water and then with a 6N hydrochloric acid solution. The residual chestnut-brown oil is purified on a flash silica column eluted with an AcOEt/PE gradient.

1. temperatureis heated
2. temperatureat reflux for 48 hours
3. customAfter the solvent has been partially removed
4. extractionthe products are extracted with ethyl acetate
5. washwashed with water
6. customThe residual chestnut-brown oil is purified on a flash silica column
7. washeluted with an AcOEt/PE gradient