Butyryl chloride → HCID 18177428, compound

HRID 428204Notes

Reaction equation

HRID 428204 reaction equation
[CH2:1]([O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[O:13][CH2:12][C:11]([CH2:17][NH2:18])=[CH:10]2)[CH2:2][CH2:3][CH2:4][CH3:5].[C:19](Cl)(=[O:23])[CH2:20][CH2:21][CH3:22]>>[CH2:1]([O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[O:13][CH2:12][C:11]([CH2:17][NH:18][C:19](=[O:23])[CH2:20][CH2:21][CH3:22])=[CH:10]2)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

3

Reactant 2

HCID 8855Butyryl chlorideHCID 18177431HCID 18177431, compound

Product 1

HCID 18177428HCID 18177428, compound

Procedure

0.37 g (1.5 mmol) of the amine obtained in Step F of Example 55 is condensed with butanoyl chloride according to the same procedure as in Example 54. Purification on a silica column (eluant:ethyl acetate/petroleum ether 50/50) allows isolation of the title amide in the form of a yellowish solid.

Workup

  1. customPurification on a silica column (eluant:ethyl acetate/petroleum ether 50/50)

Sources & evidence

ORD record
ord-7ebabce576484fceaa75f796379a0436
Source dataset
uspto-grants-2001_11
Patent number
US06313160B1

Reaction notes

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