Ammonium Chloride → HCID 131722969, compound

Participants

Reaction Steps

This solution is introduced dropwise into a solution of 15.4 g (42.3 mmol) of 3,5-di-tert-butyl-4-(2-trimethylsilylethoxymethoxy)benzaldehyde in 50 ml of THF at −78° C. The reaction medium is allowed to return to room temperature, poured into aqueous ammonium chloride solution and extracted with ethyl ether and the organic phase is separated out after settling has taken place, dried over magnesium sulphate and evaporated. 18.5 g (95%) of the expected alcohol are obtained in the form of a yellow oil.

Provenance & Evidence