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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 428233Generated: October 26, 2026

Methyl chloroformate → Ethyl 3-[3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphth-2-yl]propiolate

https://huagongshe.com/reaction/428233

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl chloroformateHCID 6586—
ReactantEthyl 3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)propiolateHCID 11000580—
Reactant1,1,4,4,7-Pentamethyl-6-ethynyl-1,2,3,4-tetrahydronaphthaleneHCID 11806387—
ReactantButyllithiumHCID 178418339—
ProductEthyl 3-[3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphth-2-yl]propiolateHCID 18357952—

Reaction Steps

Employing the same general procedure as used for the preparation of ethyl 3-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl]propiolate (Compound A), but instead using 1.9 g of (3-methyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)ethyne, 940 mgs (10 mmols) of methylchloroformate and 8.8 mmols of n-butyllithium the title compound was obtained as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06313163B1
Source datasetuspto-grants-2001_11
ORD IDord-fb14b1dfc3f94e1b97b1e0cb25dc75ea
Source noteuspto-grants-2001_11