HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroformate → Methyl 3-(4,4-dimethyl-chroman-6-yl)propiolate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Ethyl 3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)propiolate | HCID 11000580 | — |
| Reactant | 4,4-Dimethyl-6-ethynylchroman | HCID 15616994 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | Methyl 3-(4,4-dimethyl-chroman-6-yl)propiolate | HCID 18357965 | — |
Reaction Steps
Employing the same general procedure as used for the preparation of ethyl 3-[5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-naphth-2-yl]propiolate (Compound A) but instead using 1.86 g (10 mmols) of [4,4-dimethyl-chroman-6-yl]ethyne, 2 g (21.3 mmols) of methylchloroformate and 11 mmols of n-butyllithium the title compound was obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313163B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-5d492df4c9b04e778690fd1e14a44670 |
| Source note | uspto-grants-2001_11 |