5-Nitro-2-oxindole → 5-Amino-2-oxindole

HRID 428238Notes

Reaction equation

HRID 428238 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2

Participants

4

Reactant 1

HCID 2303665-Nitro-2-oxindole

Product 1

HCID 27732135-Amino-2-oxindoleYield 60%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5-Nitro-2-oxindole (6.3 g) was hydrogenated in methanol over 10% palladium on carbon to give 3.0 g (60% yield) of the title compound as a white solid.

Sources & evidence

ORD record
ord-d338c0c3414a4821a047cfe2a9d79e3b
Source dataset
uspto-grants-2001_11
Patent number
US06313158B1

Reaction notes

Loading…