HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(chlorocarbonyl)benzoate → 5-(4-Methoxycarbonylbenzamido)-2-oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(chlorocarbonyl)benzoate | HCID 81850 | — |
| Reactant | 5-Amino-2-oxindole | HCID 2773213 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5-(4-Methoxycarbonylbenzamido)-2-oxindole | HCID 23289962 | 81% |
Reaction Steps
A mixture of 82.0 mg 5-amino-2-oxindole and 131.0 mg 4-methoxycarbonylbenzoyl chloride in pyridine was stirred at room temperature for 3 hr and poured into ice water. The precipitate was filtered, washed with water and dried in a vacuum oven to give 138.0 mg of 5-(4-methoxycarbonylbenzamido)-2-oxindole (81% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313158B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-e216cb2d01bd4e29997cdedd35322d3f |
| Source note | uspto-grants-2001_11 |