Ammonium formate → HCID 15895829, compound

Participants

Reaction Steps

To a solution of 2-methoxy-2′-methyl-4-(2-nitrophenylamino)benzophenone (Compound 255, 1.02 g, 2.8 mmol) in methanol (10 ml) was added, under argon, ammonium formiate (0.80 g, 13 mmol) and 10% palladium on carbon (0.16 g). The reaction mixture was stirred at room temperature for 16 hours. The mixture was filtered through Celite® and evaporated in vacuo. The residue was treated with water (50 ml) and extracted with methylene chloride (2×50 ml). The organic phase was dried (MgSO4), filtered and evaporated in vacuo to afford the crude product which was further purified by chromatography using ethyl acetate/pentane 1:1 as eluant.

Provenance & Evidence