Propyl isocyanate → HCID 18358241, compound

HRID 428300Notes

Reaction equation

HRID 428300 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[CH:22]=[CH:21][C:12]([C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:14])=[CH:11][CH:10]=1.[CH2:23]([N:26]=[C:27]=[O:28])[CH2:24][CH3:25]>C1(C)C=CC=CC=1>[C:13]([C:12]1[CH:21]=[CH:22][C:9]([NH:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:27]([NH:26][CH2:23][CH2:24][CH3:25])=[O:28])=[CH:10][CH:11]=1)(=[O:14])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 61033Propyl isocyanateHCID 11737779{4-[(2-Aminophenyl)amino]phenyl}(Phenyl)methanone2×

Product 1

HCID 18358241HCID 18358241, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of 4-(2-aminophenylamino)benzophenone (Compound 101, 0.58 g, 2 mmol) in toluene (10 ml) was added n-propylisocyanate (0.23 ml, 2.4 mmol). The reaction mixture was heated for 4 hours on a steam bath. After cooling the reaction mixture to room temperature the resulting precipitate was collected by filtration and washed with toluene. The crude product was dissolved in hot isopropanol and crystallized on cooling to afford the title compound.

Workup

  1. temperatureThe reaction mixture was heated for 4 hours on a steam bath
  2. filtrationwas collected by filtration
  3. washwashed with toluene
  4. dissolutionThe crude product was dissolved in hot isopropanol
  5. customcrystallized
  6. temperatureon cooling

Sources & evidence

ORD record
ord-f8c8588bcb8f416eafa17e7f79907806
Source dataset
uspto-grants-2001_11
Patent number
US06313174B1

Reaction notes

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