4-Nitrobenzyl bromide → HCID 70112007, compound
Reaction equation
[CH2:1]([O:8][CH2:9][C@H:10]([C@H:19]([C@@H:21]([C@@H:23]([CH2:25][O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[OH:24])[OH:22])[OH:20])[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:34]([C:37]1[CH:44]=[CH:43][C:40]([CH2:41]Br)=[CH:39][CH:38]=1)([O-:36])=[O:35]>>[CH2:1]([O:8][CH2:9][C@H:10]([C@H:19]([C@@H:21]([C@@H:23]([CH2:25][O:26][CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[O:24][CH2:41][C:40]1[CH:43]=[CH:44][C:37]([N+:34]([O-:36])=[O:35])=[CH:38][CH:39]=1)[OH:22])[OH:20])[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
3
Procedure
The product of example 71 was further alkylated with 4-nitrobenzyl bromide affording after purification by flash chromatography the title compound.
Workup
- customafter purification by flash chromatography the title compound
Sources & evidence
- ORD record
- ord-6cd84a29a11a4b3db2299a15472e1932
- Source dataset
- uspto-grants-2001_11
- Patent number
- US06313177B1
Reaction notes
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