Hydrogen Peroxide → HCID 20701211, compound

Participants

Reaction Steps

(S)-N,N-Diisopropyl-3-(2-benzyloxy-5-ethenylphenyl)-3-phenylpropanamine (1 g, 2.34 mmol) in THF (25 mL) was added to 9-BBN (0.5 M in THF, 11.7 mL, 5.85 mmol) under nitrogen atmosphere at 0° C. Additional 9-BBN (2.3 mL, 1.2 mmol) was added after 3 hours of stirring, the temperature was raised to room temperature and the mixture was stirred for 0.5 hour. It was then cooled to 0° C. and 1 M sodium hydroxide (10 mL) was added followed by H2O2 (30% in H2O, 10 mL). After 1 hours stirring, water was added and the mixture was extracted with diethyl ether. The organic layer was washed with water and brine, dried (MgSO4) and concentrated. The residue was chromatographed on silica (gradient of diethyl ether to 1% NH3 in diethyl ether). Yield 0.67 g (64%). 1H NMR (CDCl3) δ0.90 (d, 12H), 2.10-2.18 (m, 2H), 2.30-2.37 (m, 2H), 2.80 (t, 2H), 2.90-3.0 (m, 2H), 3.80 (br, 2H), 4.40 (t, 1H), 5.0 (s, 2H), 6.80 (d, 1H), 7.0 (m, 1H), 7.10-7.38 (m, 11H).

Provenance & Evidence