Styrene → HCID 11065845, compound

HRID 428369Notes

Reaction equation

HRID 428369 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[CH2:14]=[CH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[Li]CCCC>>[C:16]1([CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][N:8]([C:4]3[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][CH:5]=3)[CH2:9][CH2:10]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 7501StyreneHCID 831111-(m-Tolyl)piperazineHCID 178418339Butyllithium

Product 1

HCID 11065845HCID 11065845, compound

Procedure

According to GP, 2.22 mmol (=0.39 g) of 1-(3-methylphenyl)piperazine and 2.22 mmol (=0.23 g=0.25 ml) of styrene are reacted with 5 mol % (=0.111 mmol=70 μl) of n-BuLi solution. Column-chromatographic separation with ethyl acetate gives the product 4-(2-phenyl-1-ethyl)-1-(3-tolyl)piperazine as a light-brown solid.

Workup

  1. customColumn-chromatographic separation with ethyl acetate

Sources & evidence

ORD record
ord-a5d8a3407d984c59b7d1f21075fc9f1f
Source dataset
uspto-grants-2001_11
Patent number
US06313297B1

Reaction notes

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