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4-Chlorostyrene → 1-(4-Fluorophenyl)-4-[2-(4-chlorophenyl)-1-ethyl]piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorostyrene | HCID 14085 | — |
| 反応物 | 1-(4-Fluorophenyl)piperazine | HCID 75260 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | 1-(4-Fluorophenyl)-4-[2-(4-chlorophenyl)-1-ethyl]piperazine | HCID 11045386 | — |
反応手順
According to GP, 2.22 mmol (=0.40 g) of 1-(4-fluorophenyl)piperazine and 2.22 mmol (=0.31 g=0.28 ml) of 4-chlorostyrene are reacted with 5 mol % (=0.111 mmol=70 μl) of n-BuLi solution. Column-chromatographic separation with ethyl acetatein-hexane gives the product 1-(4-fluorophenyl)-4-[2-(4-chlorophenyl)-1-ethyl]piperazine as a light-yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06313297B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-3820c9fd64b8451193808627ea34a7cf |
| 出典メモ | uspto-grants-2001_11 |