1-Phenylpiperazine → 1-Phenyl-4-(1-methyl-2-phenylethyl)piperazine

関与物質

反応手順

According to GP, 2.22 mmol (=0.36 g=0.34 ml) of phenylpiperazine and 2.22 mmol (=0.26 g=0.29 ml) of β-trans-methylstyrene are reacted with 5 mol % (=0.111 mmol=70 μl) of n-BuLi solution. Column-chromatographic separation with ethyl acetate/n-hexane (3:1) gives the product 1-phenyl-4-(1-methyl-2-phenylethyl)piperazine as a yellow solid.

情報源と証拠