反应详情

Ethyl α-cyano-5-nitro-1,2-benzisothiazole-3-acetate (6.67 g, 0.0229 mol) is added to a solution of acetyl chloride (67.0 mL) in ethanol. The reaction mixture is refluxed overnight, cooled, and filtered to remove solids. The resultant filtrate is concentrated in vacuo to obtain a brown semi-solid. A mixture of the semi-solid in diethyl ether is stirred for two hours and filtered to obtain a solid. The solid is washed with diethyl ether and air-dried to give the title product as yellow crystals (1.04 g, mp 91-92° C.)

1. temperatureThe reaction mixture is refluxed overnight
2. temperaturecooled
3. filtrationfiltered
4. customto remove solids
5. concentrationThe resultant filtrate is concentrated in vacuo
6. customto obtain a brown semi-solid
7. filtrationfiltered
8. customto obtain a solid
9. washThe solid is washed with diethyl ether
10. customair-dried