反应详情

150 mg of 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid and 320 mg of t-butyl 8-(methoxyimino)-2,6-diazaspiro[3,4]octane-2-carboxylate were added to 10 ml of acetonitrile and the resulting mixture was refluxed for 7 hours and then cooled to room temperature. The precipitated solid was filtered and dried to give 120 mg of the titled compound(yield: 55.5%).

1. temperaturethe resulting mixture was refluxed for 7 hours
2. filtrationThe precipitated solid was filtered
3. customdried