Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Indole → 3-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Indole | HCID 798 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole | HCID 2763857 | 89.1% |
반응 단계
Indole (4.69, 40 mmol), 1,4-cyclohexanedione monoethylene ketal (6.3 g, 40 mmol) and potassium hydroxide (13.2 g, 200 mmol) were heated to reflux in 70 ml methanol for 6 hours. The reaction was cooled and the product was isolated by filtration and washed with water to give 9.1 g (89%) of product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06313126B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-c231f3e905344f7da9cd7cae7f810718 |
| 출처 메모 | uspto-grants-2001_11 |