HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-Fluoroindole | HCID 67861 | — |
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole | HCID 10516380 | 87.3% |
Reaction Steps
5-Fluoroindole (4.96 g, 0.036 mol), 1,4-cyclohexanedione monoethylene ketal (7.17 g, 0.046 mol) and potassium hydroxide (6 g, 91 mmol) were heated to reflux in 70 ml methanol for 6 hours. The reaction was cooled and the product was isolated by filtration and washed with water to give 8.59 g (86%) of product as a white solid: mp 153-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313126B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-ffa2311badee405ebc69dae3b0454d87 |
| Source note | uspto-grants-2001_11 |