HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-2H-indole → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-fluoro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-2H-indole | HCID 18357033 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-fluoro-1H-indole | HCID 10564325 | 88.2% |
Reaction Steps
A mixture of of 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-2H-indole (8.5 g) and 10% palladium on carbon (2.72 g) in ethanol (200 ml) was hydrogenated for 5 hours. The catalyst was filtered off and the solvent removed under vacuum. Chromatography (methanol-methylene chloride) afforded 7.55 g (82%) of product as a white solid: mp 183-185° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313126B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-dfa4366ba7ea454f93adb5356b189843 |
| Source note | uspto-grants-2001_11 |