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3-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indole → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indole | HCID 10848753 | — |
| 反応物 | 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-6-fluoro-1H-indole | HCID 18414166 | — |
| 生成物 | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indole | HCID 18414086 | 60.7% |
反応手順
This compound was prepared in the manner described above for intermediate 2a by replacing 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-6-fluoro-1H-indole (9.54 g) to afford 5.83 g (60%) of the title compound as a white solid: mp 158-159° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06313126B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-6e9da474995f40d4953c0833c575b14b |
| 出典メモ | uspto-grants-2001_11 |