HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indole → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indole | HCID 10848753 | — |
| Reactant | 3-(1,4-Dioxaspiro[4.5]dec-7-EN-8-YL)-1H-indole-5-carbonitrile | HCID 15521972 | — |
| Product | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1H-indole | HCID 15521973 | 95% |
Reaction Steps
This compound was prepared in the manner described above for intermediate 2a by replacing 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-5-cyano-1H-indole (54.6 g) ) to afford 52.12 g (95%) of the title compound as a white solid in 95% (52.12 g) yield as a white solid: mp 153-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313126B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-31f549034ae44f53a1d3e7259dda407c |
| Source note | uspto-grants-2001_11 |