HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1H-Indol-3-YL)cyclohexanone → 4-(6-Fluoro-1H-indol-3-YL)cyclohexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1H-Indol-3-YL)cyclohexanone | HCID 10846264 | — |
| Reactant | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indole | HCID 18414086 | — |
| Product | 4-(6-Fluoro-1H-indol-3-YL)cyclohexanone | HCID 15481281 | 425.3% |
Reaction Steps
This compound was prepared in the manner described above for intermediate 3a by replacing 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indole (5.4 g) to afford 19.29 g (99%) of the title compound as a white solid: mp 102-105° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313126B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-90a87b949cc44eda85911d18e3a2c306 |
| Source note | uspto-grants-2001_11 |