4-(1H-Indol-3-YL)cyclohexanone → HCID 18414175, compound

HRID 428500Notes

Reaction equation

HRID 428500 reaction equation
N1C2C(=CC=CC=2)C(C2CCC(=O)CC2)=C1.O1[C:21]2([CH2:26][CH2:25][CH:24]([C:27]3[C:35]4[C:30](=[CH:31][CH:32]=[C:33]([Br:36])[CH:34]=4)[NH:29][CH:28]=3)[CH2:23][CH2:22]2)[O:20]CC1>>[Br:36][C:33]1[CH:34]=[C:35]2[C:30](=[CH:31][CH:32]=1)[NH:29][CH:28]=[C:27]2[CH:24]1[CH2:23][CH2:22][C:21](=[O:20])[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 108462644-(1H-Indol-3-YL)cyclohexanoneHCID 18414122HCID 18414122, compound

Product 1

HCID 18414175HCID 18414175, compoundYield 84.4%

Procedure

This compound was prepared in the manner described above for intermediate 3a by replacing 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-5-bromo-1H-indole (4.5 g) to afford 3.3 g (84%) of the title compound as a white solid: MS EI m/e 291 (M+).

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-a88a5008bc1b46999226db1b47f96c23
Source dataset
uspto-grants-2001_11
Patent number
US06313126B1

Reaction notes

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