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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 428510Generated: October 30, 2026

Benzyl Bromide → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-benzyl-indole

https://huagongshe.com/reaction/428510

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl BromideHCID 7498—
Reactant3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-ethyl-indoleHCID 18414062—
Product3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-benzyl-indoleHCID 1841412157%

Reaction Steps

This compound was prepared in the manner described above for intermediate 5b by replacing ethylbromide with benzylbromide (14.3 g, 84 mmol) to afford 6.04 g (57%) of the title compound as a white solid: mp 129-130° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06313126B1
Source datasetuspto-grants-2001_11
ORD IDord-c009ef33481c4c518e9748598561d70c
Source noteuspto-grants-2001_11