反应详情

To a solution of 8-(4-benzyl-piperazin-1-yl)quinoline (2.63 g, 8.7 mmol) in methylene chloride (30 ml) was added vinyl chloroformate (1.1 ml, 13 mmol) at room temperature slowly. The reaction mixture was refluxed for 2 hours, and then concentrated under vacuum. The residue was dissolved in 12 N hydrochloric acid (20 ml) and stirred at room temperature for 1 hour. The mixture was concentrated, the residue was taken up with 40 ml ethanol and heated up to 50° C. for 2 hours. The solvent was removed under vacuum, the residue was dissolved in 1 N sodium hydroxide-ethyl acetate and extracted with ethyl acetate and washed with water. The organic layer was dried over anhydrous sodium sulfate. The solvent was removed under vacuum. Chromatography (10-30% methanol -methylene chloride plus ammonium hydroxide) afforded 1.86 g (90%) yellow oil; MS EI m/e 213 (M)+.

1. temperatureThe reaction mixture was refluxed for 2 hours
2. concentrationconcentrated under vacuum
3. dissolutionThe residue was dissolved in 12 N hydrochloric acid (20 ml)
4. concentrationThe mixture was concentrated
5. temperatureheated up to 50° C. for 2 hours
6. customThe solvent was removed under vacuum
7. dissolutionthe residue was dissolved in 1 N sodium hydroxide-ethyl acetate
8. extractionextracted with ethyl acetate
9. washwashed with water
10. dry with materialThe organic layer was dried over anhydrous sodium sulfate
11. customThe solvent was removed under vacuum