N-Benzylnormechlorethamine → 1-Benzyl-4-(5-fluoro-2,3-dihydro-benzofuran-7-yl)-piperazine

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Reaction Steps

A solution of 5-fluoro-7-amino-2,3-dihydrobenzofuran (1.38 g, 9 mmol) and bis(2-chloroethyl)-benzylamine (3.14 g, 14 mmol) in butanol (20 ml) was stirred at 100° C. for 10 hours. The salt was filtered off, washed with ethyl ether (30 ml) and dried under vacuum: mp 232-233.5° C. The salt was converted to the free base to afford 2.06 g (73%) of the title compound.

Provenance & Evidence