3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole → 5-Fluoro-3-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]cyclohex-1-enyl}-1H-indole

HRID 428527Notes

Reaction equation

HRID 428527 reaction equation
O1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([F:20])[CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)OCC1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][N:32](C2CCC(=O)CC2)[CH2:31][CH2:30]1>>[F:20][C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[C:11]2[C:8]1[CH2:9][CH2:10][CH:5]([N:32]2[CH2:31][CH2:30][N:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[O:22][CH3:21])[CH2:34][CH2:33]2)[CH2:6][CH:7]=1

Participants

3

Reactant 2

HCID 105163803-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indoleHCID 105653074-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-cyclohexanone

Product 1

HCID 102013125-Fluoro-3-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]cyclohex-1-enyl}-1H-indole

Procedure

This compound was prepared in the manner described above for intermediate 1c by replacing 1,4-cyclohexanedione monoethylene ketal with 4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-cyclohexanone (1.44 g, 5 mmol). The crude mixture was used in next step without further purification.

Workup

  1. customThis compound was prepared in the manner
  2. customThe crude mixture was used in next step without further purification

Sources & evidence

ORD record
ord-4d163235a4f2465c932c57eadc689d13
Source dataset
uspto-grants-2001_11
Patent number
US06313126B1

Reaction notes

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