Ammonium formate → HCID 18414132, compound

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Reaction Steps

A mixture of 4-(4-benzyl-piperazin-1-yl)-6-methoxy-1H-indole (0.37 g, 1.1 mmol), 10% Pd/C (0.05 g) and ammonium formate (0.15 g, 2.2 mmol) in ethanol (20 mL) was allowed to reflux for 2 hours. The catalyst was filtered off and the solvent removed under vacuum. Chromatography (10% methanol/methylene chloride plus ammonium hydroxide) afforded 0.2 g (75%) of product as a yellow foam. MS (EI) m/e 231.

Provenance & Evidence