Ethyl 4-isocyanatobenzoate → 1-Methylsufonyl-n-(4-ethoxycarbonylphenyl)spiro[indoline-3,4'-piperidine]-1'-carboxamide

HRID 428581Notes

Reaction equation

HRID 428581 reaction equation
[CH3:1][S:2]([N:5]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:7]2([CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:6]1)(=[O:4])=[O:3].[N:19]([C:22]1[CH:32]=[CH:31][C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:24][CH:23]=1)=[C:20]=[O:21]>ClCCl>[CH3:1][S:2]([N:5]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:7]2([CH2:8][CH2:9][N:10]([C:20]([NH:19][C:22]3[CH:23]=[CH:24][C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:31][CH:32]=3)=[O:21])[CH2:11][CH2:12]2)[CH2:6]1)(=[O:3])=[O:4]

Participants

4

Reactant 2

HCID 589805Ethyl 4-isocyanatobenzoateHCID 111400731-(Methylsulfonyl)spiro[indoline-3,4'-piperidine]

Product 1

HCID 180048821-Methylsufonyl-n-(4-ethoxycarbonylphenyl)spiro[indoline-3,4'-piperidine]-1'-carboxamideYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 1-methylsulfonyl-spiro[indoline-3,4′-piperidine] (2.66 g, 10 mmol) in dichloromethane (50 mL), was added ethyl 4-isocyanatobenzoate (1.91 g, 10 mmol) at room temperature. The resulting solution was stirred for four hours during which time precipitation occurred. The mixture was evaporated to remove dichloromethane, and then was suspended in methanol (20 mL), filtration followed by washing with cold methanol gave 1500 as a white solid (4.56 g, 100%)

Workup

  1. customThe mixture was evaporated
  2. customto remove dichloromethane
  3. filtrationfiltration
  4. washby washing with cold methanol

Sources & evidence

ORD record
ord-ca81d50262114ca4b17a4d14d1d5aabc
Source dataset
uspto-grants-2001_11
Patent number
US06313298B1

Reaction notes

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