HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 3-fluoro-4-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3-Fluoro-4-nitrobenzoic acid | HCID 230653 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 3-fluoro-4-nitrobenzoate | HCID 592761 | 96% |
Reaction Steps
A mixture of 3-fluoro-4-nitrobenzoic acid(2.07 g, 11.2 mmol) and cH2SO4(0.5 ml) in MeOH(10 ml) was refluxed for 8 h. The solvent was evapolated. The residue was dissolved in AcOEt and washed with saturated NaHCO3 aqueous solution, water, brine, dried (Na2SO4), and concentrated to give 2.14 g(96%) of ivory solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313302B2 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-87d1ead1242f4920bb9a654a17f43691 |
| Source note | uspto-grants-2001_11 |