HCID 15550409, compound → HCID 20640604, compound

HRID 428594Notes

Reaction equation

C1([C@@H](N2CC[C@H](OC3CCCCO3)C2)CO)C=CC=CC=1.[C:22]1([C@H:28](O)[CH2:29][N:30]2[CH2:34][CH2:33][C@H:32]([O:35][CH:36]3[CH2:41][CH2:40][CH2:39][CH2:38][O:37]3)[CH2:31]2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[Cl:43][C:44]1[CH:53]=[C:52]([NH:54][CH3:55])[CH:51]=[CH:50][C:45]=1[C:46]([O:48][CH3:49])=[O:47]>>[Cl:43][C:44]1[CH:53]=[C:52]([N:54]([C@@H:28]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:29][N:30]2[CH2:34][CH2:33][C@H:32]([O:35][CH:36]3[CH2:41][CH2:40][CH2:39][CH2:38][O:37]3)[CH2:31]2)[CH3:55])[CH:51]=[CH:50][C:45]=1[C:46]([O:48][CH3:49])=[O:47]

Participants

Reactant 3

HCID 15550409HCID 15550409, compound

HCID 15550410HCID 15550410, compound

HCID 15907753HCID 15907753, compound

Product 1

HCID 20640604HCID 20640604, compoundYield 40%

Procedure

This was prepared from 2-(R)-phenyl-2-(3-(S)-tetrahydropyran-2-yloxypyrrolidin-1-yl)ethanol and 1-(S)-phenyl-2-(3-(S)-tetrahydropyran-2-yloxypyrrolidin-1-yl)ethanol and methyl 2-chloro-4-methylaminobenzoate in 40% yield according to a procedure similar to that described in Example 1 (i).

Sources & evidence

ORD record: ord-17163ce28a5a46419c1229b7dae645e6
Source dataset: uspto-grants-2001_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06313302B2

Reaction notes

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