HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenyethanol → Methyl 6-{N-[2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenyethyl]-N-methylamino}nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenyethanol | HCID 15520998 | — |
| Reactant | 2-(3-(S)-methoxymethoxypyrrolidin-1-y)-2-(R)-phenylethanol | HCID 15520999 | — |
| Reactant | Methyl 6-(methylamino)pyridine-3-carboxylate | HCID 15541447 | — |
| Product | Methyl 6-{N-[2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenyethyl]-N-methylamino}nicotinate | HCID 54571353 | 60% |
Reaction Steps
This was prepared from 2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenylethanol and 2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-2-(R)-phenylethanol and methyl 6-methylaminonicotinate in 60% yield according to a procedure similar to that described in Example 29 (i).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313302B2 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-148ffcfa08494622bfe958cd06dbc205 |
| Source note | uspto-grants-2001_11 |