反应详情

4-(5-Chloro-1,2,3,4-tetrahydronaphthalen-1-yl)-1H-imidazole (300 mg) is dissolved in ethanol (15 ml). The reaction solution is hydrogenated at 50° C. with 10% palladium on carbon as catalyst for 8 hours. The mixture is filtered to remove the catalyst, and the filtrate is evaporated under reduced pressure. The residue is dissolved in water and is made alkaline with sodium hydroxide solution. The product is extracted into methylene chloride which is washed with water, dried with sodium sulfate and evaporated under reduced pressure. The crude product is recrystallized from ethyl acetate. The yield is 169 mg, m.p. 105-110° C.

1. filtrationThe mixture is filtered
2. customto remove the catalyst
3. customthe filtrate is evaporated under reduced pressure
4. dissolutionThe residue is dissolved in water
5. extractionThe product is extracted into methylene chloride which
6. washis washed with water
7. dry with materialdried with sodium sulfate
8. customevaporated under reduced pressure
9. customThe crude product is recrystallized from ethyl acetate