HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 428614Generated: October 25, 2026
3-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one → 3-(3-Benzyl-3H-imidazol-4-yl)-5-isobutylindan-1-one
https://huagongshe.com/reaction/428614
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one | HCID 53707934 | — |
| Solvent | Methanesulfonic Acid | HCID 6395 | — |
| Product | 3-(3-Benzyl-3H-imidazol-4-yl)-5-isobutylindan-1-one | HCID 18405275 | — |
Reaction Steps
A mixture of 3-(3-benzyl-3H-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one (2.4 g) and methanesulfonic acid (40 ml) is heated at 120° C. for 40 minutes. Work-up of the reaction mixture gives the crude product, which is purified by flash chromatography by eluting with methylene chloride-methanol solution. The yield is 0.5 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06313311B1 |
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| Source dataset | uspto-grants-2001_11 |
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| ORD ID | ord-c9062252c5944c8ebc5e47ba0c1e4126 |
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| Source note | uspto-grants-2001_11 |
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