3-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one → HCID 178486575, compound

HRID 428617Notes

Reaction equation

HRID 428617 reaction equation
C([N:8]1[C:12]([CH:13]2[C:21]3[C:16](=[C:17]([CH3:25])[C:18]([CH3:24])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15](=[O:26])[CH2:14]2)=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:10]1[CH:11]=[C:12]([CH:13]2[C:21]3[C:16](=[C:17]([CH3:25])[C:18]([CH3:24])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15](=[O:26])[CH2:14]2)[N:8]=[CH:9]1

Participants

4

Reactant 1

HCID 184052653-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one

Product 1

HCID 178486575HCID 178486575, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one (1.1 g) is dissolved in ethanol (90 ml). The reaction solution is hydrogenated at 50-55° C. with 10% palladium on carbon as catalyst for 7 hours. The mixture is filtered to remove the catalyst, and the filtrate is evaporated under reduced pressure. The product is converted to its hydrochloride salt in ethyl acetate using dry hydrochloric acid. The yield is 0.6 g, m.p. 258-261° C.

Workup

  1. filtrationThe mixture is filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-ee120878f08745b19a7414a1108d4a3f
Source dataset
uspto-grants-2001_11
Patent number
US06313311B1

Reaction notes

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