HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178418361, compound → 5-(2,3-dihydro-1H-inden-1-yl)-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Reactant | HCID 178419845 | HCID 178419845 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(2,3-dihydro-1H-inden-1-yl)-1H-imidazole | HCID 178419883 | — |
Reaction Steps
4-(3H-Inden-1-yl)-1H-imidazole hydrochloride (80 mg) is dissolved in ethanol (6 ml). The reaction solution is hydrogenated at 40-50° C. with 10% palladium on carbon as catalyst until no more hydrogen is consumed. Work-up of the reaction mixture gives the crude product which is purified by flash chromatography using methylene chloride-methanol as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313311B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-8b2122f263e049d1865a07c3fccc6a1c |
| Source note | uspto-grants-2001_11 |