Sulfuric Acid → HCID 178486419, compound

HRID 428624Notes

Reaction equation

HRID 428624 reaction equation
S(=O)(=O)(O)O.Cl.[CH3:7][O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH2:13][CH2:14][CH:15]2[CH2:18][C:19]2[N:20]=[CH:21][NH:22][CH:23]=2)=[CH:11][CH:10]=1.[C:24](O)([CH3:27])([CH3:26])[CH3:25].[OH-].[Na+]>O>[C:24]([C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][C:9]=1[O:8][CH3:7])[CH:15]([CH2:18][C:19]1[N:20]=[CH:21][NH:22][CH:23]=1)[CH2:14][CH2:13]2)([CH3:27])([CH3:26])[CH3:25]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 6386tert-ButanolHCID 14798Sodium HydroxideHCID 178487127HCID 178487127, compound

Product 1

HCID 178486419HCID 178486419, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
37.5 °C

Procedure

Sulfuric acid (0.5 ml) is added into the mixture of 4-(6-methoxyindan-1-ylmethyl)-1H-imidazole hydrochloride (50 mg) and tert-butanol (2 ml). The mixture is stirred at 35-40° C. for 10 hours. The reaction mixture is then poured into water and is made alkaline with sodium hydroxide. The product is extracted into methylene chloride which is washed with water, dried with sodium sulfate and evaporated to dryness. The residue consisting of crude product is converted to its hydrochloride salt in ethyl acetate. The yield is 23 mg, m.p. 174-184° C.

Workup

  1. extractionThe product is extracted into methylene chloride which
  2. washis washed with water
  3. dry with materialdried with sodium sulfate
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-1e93a7d6325b43b3ae25a13e4263b54b
Source dataset
uspto-grants-2001_11
Patent number
US06313311B1

Reaction notes

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