Sulfuric Acid → HCID 178486418, compound

HRID 428626Notes

Reaction equation

HRID 428626 reaction equation
S(=O)(=O)(O)O.Cl.[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]([CH2:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1)[CH2:14][CH2:13][CH2:12]2.[C:25](O)([CH3:28])([CH3:27])[CH3:26].[OH-].[Na+]>O>[C:25]([C:18]1[CH:17]=[C:16]2[C:11]([CH2:12][CH2:13][CH2:14][CH:15]2[CH2:19][C:20]2[N:21]=[CH:22][NH:23][CH:24]=2)=[CH:10][C:9]=1[O:8][CH3:7])([CH3:28])([CH3:27])[CH3:26]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 6386tert-ButanolHCID 14798Sodium HydroxideHCID 178487148HCID 178487148, compound

Product 1

HCID 178486418HCID 178486418, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
37.5 °C

Procedure

Sulfuric acid (0.75 ml) is added into the mixture of 4-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-1H-imidazole hydrochloride (75 mg) and tert-butanol (3 ml). The mixture is stirred at 35-40° C. for 15 hours. The reaction mixture is poured into water and is made alkaline with sodium hydroxide. The product is extracted into methylene chloride which is washed with water, dried with sodium sulfate and evaporated to dryness. The residue consisting of crude product is coverted to its hydrochloride salt in ethyl acetate. The yield is 40 mg.

Workup

  1. extractionThe product is extracted into methylene chloride which
  2. washis washed with water
  3. dry with materialdried with sodium sulfate
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-d794a2d4779a4b488ebc62bc7f4cb26b
Source dataset
uspto-grants-2001_11
Patent number
US06313311B1

Reaction notes

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