Water → HCID 178515306, compound

Participants

Reaction Conditions

Reaction Steps

Bromine (130 mg, 1 eq.) is added dropwise to a stirred suspension of 3-(1H-imidazol-4-ylmethyl)-indan-5-ol hydrochloride (130 mg) in acetic acid (6 ml). The mixture is stirred at 20-23° C. for 3 hours. The reaction mixture is then poured into water and is made alkaline with ammonium hydroxide solution. The product is extracted into ethyl acetate which is washed with water, dried with sodium sulfate and evaporated to dryness. The product is purified by flash chromatography using methylene chloride-methanol as eluent and is then converted to the hydrochloride salt in ethyl acetate-ethanol solution.

Provenance & Evidence