Water → HCID 178519268, compound

HRID 428631Notes

Reaction equation

HRID 428631 reaction equation
[BH4-].[Na+].[OH:3][C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][CH:10]2[CH2:13][C:14]2[N:15]=[CH:16][NH:17][CH:18]=2)=[CH:6][C:5]=1[CH:19]=[O:20].O>C(O)C>[OH:20][CH2:19][C:5]1[CH:6]=[C:7]2[C:11]([CH:10]([CH2:13][C:14]3[N:15]=[CH:16][NH:17][CH:18]=3)[CH2:9][CH2:8]2)=[CH:12][C:4]=1[OH:3]

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 178519267HCID 178519267, compound

Product 1

HCID 178519268HCID 178519268, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium borohydride (8 mg) is added into a solution of 6-hydroxy-1-(1H-imidazol-4-ylmethyl)-indan-5-carbaldehyde (44 mg) in ethanol (6 ml). The mixture is stirred at room temperature for one hour and then poured into water. The product is extracted into ethyl acetate which is washed with water, dried with sodium sulfate and evaporated to dryness. The crude product is purified by flash chromatography using methylene chloride-methanol as eluent and crystallized from ethyl acetate.

Workup

  1. extractionThe product is extracted into ethyl acetate which
  2. washis washed with water
  3. dry with materialdried with sodium sulfate
  4. customevaporated to dryness
  5. customThe crude product is purified by flash chromatography
  6. customcrystallized from ethyl acetate

Sources & evidence

ORD record
ord-4dddb772510246108a7b851bfeb1e145
Source dataset
uspto-grants-2001_11
Patent number
US06313311B1

Reaction notes

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