Nitric Acid → 1,3-dihydro-4-iodo-5-nitro-2H-indol-2-one

Participants

Reaction Steps

A mixture of concentrated sulfuric acid (0.73 mL) and concentrated nitric acid (0.14 mL) was added slowly to a solution of 1,3-dihydro-4-iodo-2H-indol-2-one (0.5 g, 1.93 mmol) (see Fukuyama, supra) in concentrated sulfuric acid (6 mL) at −5° C., with stirring. The mixture was stirred for an additional 15 min at −5° C., then poured onto ice. After standing for 1 h, solid was collected by filtration and washed with water, and dried in a vacuum oven to give 1,3-dihydro-4-iodo-5-nitro-2H-indol-2-one. (Yield 0.46 g, 78%).

Provenance & Evidence