Lithium hydroxide, monohydrate → HCID 10180013, compound

Participants

Reaction Steps

Using Method F above, 4-[1-hydroxy-3-[3-(3-methoxy-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-4-yl]-prop-2-ynyl]-benzoic acid methyl ester (30 mg, 0.07 mmol) (from Example 12 above) was hydrolyzed with LiOH.H2O (13 mg, 2.7 mmol) in THF (1 mL) and water (1 mL) at room temperature for 18 h, to yield rac-(Z)-4-[3-[2,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-1H-indol-4-yl]-1-hydroxy-2-propynyl]benzoic acid. (Yield 21 mg, 72%).

Provenance & Evidence