HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-1H-pyrrole-2-carbaldehyde → α-Ethynyl-1-methyl-1H-pyrrole-2-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-1H-pyrrole-2-carbaldehyde | HCID 14504 | — |
| Reactant | HCID 178462451 | HCID 178462451 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | α-Ethynyl-1-methyl-1H-pyrrole-2-methanol | HCID 18359311 | — |
Reaction Steps
3-Hydroxy-3-(1-methyl-pyrrol-2-yl)-1-propyne was prepared according to Method A above using 1-methyl-2-pyrrolecarboxaldehyde (0.450 g, 4 mmol) (Aldrich) in THF (20 mL) and ethynylmagnesium chloride (5 mmol, 10 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 422 mg, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313310B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-0f41f1de5e65435daca5aa6c0b132d11 |
| Source note | uspto-grants-2001_11 |