HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4,5-Trimethoxybenzaldehyde → 3-Hydroxy-3-(2,4,5-trimethoxyphenyl)-1-propyne
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4,5-Trimethoxybenzaldehyde | HCID 20525 | — |
| Reactant | HCID 178462451 | HCID 178462451 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Hydroxy-3-(2,4,5-trimethoxyphenyl)-1-propyne | HCID 18359226 | — |
Reaction Steps
3-Hydroxy-3-(2,4,5-trimethoxyphenyl)-1-propyne was prepared according to Method A above from 2,4,5-trimethoxybenzaldehyde (0.784 g, 4 mmol) (Aldrich) in THF (20 mL) and ethynylmagnesium chloride (5 mmol, 10 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 548 mg, 71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313310B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-8abde0dc567c4c4f8bd01565a73b75e0 |
| Source note | uspto-grants-2001_11 |