HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Benzodioxole-5-carboxaldehyde, 7-methoxy- → 3-Hydroxy-3-(4-methoxy-1,3-benzodioxol-6-yl)-1-propyne
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Benzodioxole-5-carboxaldehyde, 7-methoxy- | HCID 22016 | — |
| Reactant | HCID 178462451 | HCID 178462451 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Hydroxy-3-(4-methoxy-1,3-benzodioxol-6-yl)-1-propyne | HCID 18359297 | — |
Reaction Steps
3-Hydroxy-3-(4-methoxy-1,3-benzodioxol-6-yl)-1-propyne was prepared according to Method A above from 3-methoxy-4,5-methylenedioxybenzaldehyde (0.721 g, 4 mmol) (Lancaster) in THF (20 mL) and ethynylmagnesium chloride (5 mmol, 10 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 629 mg, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313310B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-09f09693986d43fa958bb0be9160d046 |
| Source note | uspto-grants-2001_11 |